Objective Gut microbiota may promote positive energy balance; however, germfree mice can
be either resistant or susceptible to diet-induced obesity (DIO) depending on the type of …

Obesity in pet dogs and cats is a significant problem in developed countries, and seems to
be increasing in prevalence. 1 In dogs and cats, as in other species, accumulation of excess …

Obesity and its associated medical conditions continue to increase and add significant
burden to patients, as well as health-care systems, worldwide. Bariatric surgery is the most …

Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in
meaningful weight loss in obese individuals. To further understand the mechanisms …

Leptin has been believed to exert its weight-reducing action not only by inducing
hypophagia but also by increasing energy expenditure/thermogenesis. Leptin-deficient …

Cachexia represents a fatal energy-wasting syndrome in a large number of patients with
cancer that mostly results in a pathological loss of skeletal muscle and adipose tissue. Here …

Many postnatal onset neurological disorders such as autism spectrum disorders (ASDs) and
intellectual disability are thought to arise largely from disruption of excitatory/inhibitory …

Despite significant advances in our understanding of the biology determining systemic
energy homeostasis, the treatment of obesity remains a medical challenge. Activation of …

De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires
glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate …

Abstract The Keap1/Nrf2 pathway, known to regulate the expression of a series of
cytoprotective and antioxidant genes, has been studied in the context of obesity and type 2 …