The role of skeletal muscle in amyotrophic lateral sclerosis
JP Loeffler, G Picchiarelli, L Dupuis… - Brain …, 2016 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal adult‐onset disease primarily characterized by
upper and lower motor neuron degeneration, muscle wasting and paralysis. It is increasingly …
upper and lower motor neuron degeneration, muscle wasting and paralysis. It is increasingly …
[HTML][HTML] Skeletal muscle satellite cells, mitochondria, and microRNAs: their involvement in the pathogenesis of ALS
S Tsitkanou, PA Della Gatta, AP Russell - Frontiers in physiology, 2016 - frontiersin.org
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a fatal
motor neuron disorder. It results in progressive degeneration and death of upper and lower …
motor neuron disorder. It results in progressive degeneration and death of upper and lower …
ALS‐linked protein disulfide isomerase variants cause motor dysfunction
Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic
lateral sclerosis (ALS). Protein disulfide isomerases (PDI s) are ER foldases identified as …
lateral sclerosis (ALS). Protein disulfide isomerases (PDI s) are ER foldases identified as …
Strictly monitored exercise programs reduce motor deterioration in ALS: preliminary results of a randomized controlled trial
The objective of our study was to perform a randomized controlled trial (RCT) aimed to
evaluate the effects of three strictly monitored exercise programs (SMEP) compared to …
evaluate the effects of three strictly monitored exercise programs (SMEP) compared to …
[HTML][HTML] Complement activation at the motor end-plates in amyotrophic lateral sclerosis
N Bahia El Idrissi, S Bosch, V Ramaglia… - Journal of …, 2016 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative
disease with no available therapy. Components of the innate immune system are activated …
disease with no available therapy. Components of the innate immune system are activated …
AMPK signalling and defective energy metabolism in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is caused by selective loss of upper and lower motor
neurons by complex mechanisms that are incompletely understood. Motor neurons are …
neurons by complex mechanisms that are incompletely understood. Motor neurons are …
[HTML][HTML] Synaptic failure: focus in an integrative view of ALS
From early description by Charcot, the classification of the Amyotrophic Lateral Sclerosis
(ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a …
(ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a …
[HTML][HTML] Unchanged neurotrophic factors and their receptors correlate with sparing in extraocular muscles in amyotrophic lateral sclerosis
VM Harandi, ARN Gaied, T Brännström… - … & visual science, 2016 - iovs.arvojournals.org
Purpose: To investigate the impact of amyotrophic lateral sclerosis (ALS) on the extraocular
muscles (EOMs) by examining the distribution of neurotrophic factors (NTFs) and their …
muscles (EOMs) by examining the distribution of neurotrophic factors (NTFs) and their …
[HTML][HTML] Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to …
D Beqollari, CF Romberg, G Dobrowolny, M Martini… - Skeletal muscle, 2016 - Springer
Background Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative
disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the …
disorder that is typically fatal within 3–5 years of diagnosis. While motoneuron death is the …
[HTML][HTML] Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS
The neuromuscular junction (NMJ) allows the transformation of a neuronal message into a
mechanical force by muscle contraction and is the target of several neuromuscular …
mechanical force by muscle contraction and is the target of several neuromuscular …