Abstract Nitric oxide (NO)–cyclic 3′-5′ guanosine monophosphate (cGMP) signaling
plays a critical role on smooth muscle tone, platelet activity, cardiac contractility, renal …

Cerebral small vessel disease (SVD) is a major contributor to stroke, and a leading cause of
cognitive impairment and dementia. Despite the devastating effects of cerebral SVD, the …

Patients with advanced breast cancer often fail to respond to treatment, creating a need to
develop novel biomarkers and effective therapeutics. Dopamine (DA) is a catecholamine …

Methylene blue (MB) has received much attention in the perioperative and critical care
literature because of its ability to antagonize the profound vasodilation seen in distributive …

Soluble guanylate cyclase (sGC) is a receptor for nitric oxide (NO). Binding of NO to ferrous
(Fe 2+) heme increases its catalytic activity, leading to the production of cGMP from GTP …

Asthma is defined by airway inflammation and hyperresponsiveness, and contributes to
morbidity and mortality worldwide. Although bronchodilation is a cornerstone of treatment …

Objective To review contemporary knowledge concerning the innovative trends and
perspectives in the treatment of erectile dysfunction (ED). Methods Medline was reviewed for …

Erectile dysfunction (ED) related to compromise of the nervous system is an increasingly
common occurrence. This may be due to the multifactorial nature of ED, the myriad of …

cAMP-response element-binding protein (CREB) plays a central role in various aspects of
central nervous system (CNS) function, ranging from the developmental stages to neuronal …

The intracellular nucleotide cyclic guanosine monophosphate (cGMP) is found in many
human organ tissues. Its concentration increases in response to the activation of receptor …