A surprise that has emerged from transcriptomics is the prevalence of genomic antisense
transcription, which occurs counter to gene orientation. While frequent, the roles of antisense …

Every ribonucleic acid begins its cellular life as a transcript. If the transcript or its processing
product has a function it should be regarded an RNA. Nonfunctional transcripts, by-products …

Activation of the inducible caspase 9 (iC9) safety gene by a dimerizing drug (chemical
inducer of dimerization (CID) AP1903) effectively resolves the symptoms and signs of graft …

An important goal of synthetic biology involves the extension and standardization of novel
biological elements for applications in medicine and biotechnology. Transcriptional …

Transcriptional interference (TI), where transcription from a promoter is inhibited by the
activity of other promoters in its vicinity on the same DNA, enables transcription factors to …

Long non-coding RNA (lncRNA) transcription into a downstream promoter frequently results
in transcriptional interference. However, the mechanism of this repression is not fully …

We have investigated transcriptional interference between convergent genes in E. coli and
demonstrate substantial interference for inter-promoter distances of as far as 3 kb …

Safety switches are becoming relevant for the clinical translation of T-cell–based
immunotherapies. In patients receiving an allogeneic hematopoietic stem cell transplant, the …

Background Over the past years there are increasing evidences that the interplay between
two molecules of RNA polymerases, initiating transcription from promoters, oriented in …

We introduce exclusion models of two distinguishable species of hard rods with their distinct
sites of entry and exit under open boundary conditions. In the first model both species of …