Highlights•AAV exploits a spectrum of endocytic pathways after cellular uptake.•AAV
trafficking through the trans-Golgi network precedes nuclear entry.•Second-strand synthesis …

MicroRNAs (miRNAs) have important roles in post-transcriptional regulation of gene
expression. During viral infection, viruses utilize hosts to enhance their replication by …

Adeno-associated virus (AAV) vector-mediated delivery of inhibitors of blood–retinal barrier
breakdown (BRBB) offers promise for the treatment of diabetic macular edema. Here, we …

Adeno-associated virus (AAV) gene transfer is a promising treatment for genetic
abnormalities. Optimal AAV vectors are showing success in clinical trials. Gene transfer to …

Despite the unprecedented beneficial effects of rAAV gene therapy in animal models of
Duchenne muscular dystrophy (DMD), the need to inject large amounts of vector in vivo to …

Over the last years, ground-breaking success has been achieved in the field of human gene
therapy (ie, the correction of diseases at the genetic level), culminating in the approval of the …

Vectors derived from the Adeno-associated virus (AAV) have emerged as an efficient system
for in vivo gene transfer. However, despite their low immunogenicity and good tolerance in …

Актуальность работы. За долгое время совместной эволюции c организмомхозяином
вирусы смогли развить самые разнообразные стратегии проникновения в хозяйский …

Adeno-associated virus (AAV) gene therapy vectors, amongst others, have been shown as
safe and effective. We compared the post-entry events of mutant capsids to evaluate …

Adeno-associated virus is widely studied due to the promise it holds as a gene therapy
vector. Gene therapy broadly describes strategies in which genetic material is introduced …