Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …

CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty
liver disease, but it has been unclear whether it is simply a marker or whether it directly …

In obesity, macrophages and other immune cells accumulate in insulin target tissues,
promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin …

Nonalcoholic fatty liver disease (NAFLD) is a risk factor for type 2 diabetes (T2D), but
whether NAFLD plays a causal role in the pathogenesis of T2D is uncertain. One proposed …

Epidemiological studies link fructose consumption with metabolic disease, an association
attributable in part to fructose-mediated lipogenesis. The mechanisms governing fructose …

The hepatic tricarboxylic acid (TCA) cycle is central to integrating macronutrient metabolism
and is closely coupled to cellular respiration, free radical generation, and inflammation …

The tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a
search for alternative and less expensive medicines. Dandelion offers a compelling profile of …

Hepatic steatosis defined as lipid accumulation in hepatocytes is very frequently found in
adults and obese adolescents in the Western World. Etiologically, obesity and associated …