Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …
over 50 years and leading to significant biotechnological advancements in drug delivery …
Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
Smart superstructures with ultrahigh pH-sensitivity for targeting acidic tumor microenvironment: instantaneous size switching and improved tumor penetration
The currently low delivery efficiency and limited tumor penetration of nanoparticles remain
two major challenges of cancer nanomedicine. Here, we report a class of pH-responsive …
two major challenges of cancer nanomedicine. Here, we report a class of pH-responsive …
Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake
Nanoparticles (NPs) are functionalized with targeting ligands to enable selectively delivering
drugs to desired locations in the body. When these functionalized NPs enter the blood …
drugs to desired locations in the body. When these functionalized NPs enter the blood …
Advances in silica based nanoparticles for targeted cancer therapy
Targeted delivery of anticancer drug specifically to tumor site without damaging normal
tissues has been the dream of all scientists fighting against cancer for decades. Recent …
tissues has been the dream of all scientists fighting against cancer for decades. Recent …
[HTML][HTML] Effects of Size and Surface Charge of Polymeric Nanoparticles on in Vitro and in Vivo Applications
Biodegradable polymeric materials are the most common carriers for use in drug delivery
systems. With this trend, newer drug delivery systems using targeted and controlled release …
systems. With this trend, newer drug delivery systems using targeted and controlled release …
Carbohydrate-based amphiphilic nano delivery systems for cancer therapy
K Liu, X Jiang, P Hunziker - Nanoscale, 2016 - pubs.rsc.org
Nanoparticles (NPs) are novel drug delivery systems that have been attracting more and
more attention in recent years, and have been used for the treatment of cancer, infection …
more attention in recent years, and have been used for the treatment of cancer, infection …
Designer protein delivery: From natural to engineered affinity-controlled release systems
MM Pakulska, S Miersch, MS Shoichet - Science, 2016 - science.org
BACKGROUND Protein therapeutics constitute a multibillion-dollar market, yet their
formulation and sustained delivery still pose a substantial challenge. Controlled release …
formulation and sustained delivery still pose a substantial challenge. Controlled release …
[HTML][HTML] Development of cell-SELEX technology and its application in cancer diagnosis and therapy
M Chen, Y Yu, F Jiang, J Zhou, Y Li, C Liang… - International journal of …, 2016 - mdpi.com
SELEX (systematic evolution of ligands by exponential enrichment) is a process involving
the progressive isolation of high selective ssDNA/RNA from a combinatorial single-stranded …
the progressive isolation of high selective ssDNA/RNA from a combinatorial single-stranded …
[HTML][HTML] Aptamer-mediated targeted delivery of therapeutics: An update
S Catuogno, CL Esposito, V De Franciscis - Pharmaceuticals, 2016 - mdpi.com
The selective delivery of drugs in a cell-or tissue-specific manner represents the main
challenge for medical research; in order to reduce the occurrence of unwanted off-target …
challenge for medical research; in order to reduce the occurrence of unwanted off-target …