Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

Dysregulation of autophagy in cardiomyocytes is implicated in various heart disease
conditions. Beclin 1, a mammalian ortholog of yeast Atg6 and a core component of the …

Ferroptosis, a recently identified form of non-apoptotic cell death, is involved in several
physiological and pathological processes. Although lipid peroxidation plays a central role in …

Ferroptosis is a form of non-apoptotic cell death originally identified in cancer cells.
However, the key regulator of ferroptosis in mitochondria remains unknown. Here, we show …

Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac
intensive care units. Immunometabolism has been linked to sepsis; however, the precise …

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

Bone marrow injury remains a serious concern in traditional cancer treatment. Ferroptosis is
an iron-and oxidative-dependent form of regulated cell death that has become part of an …

Autophagy is a cell survival process which is related to breaking down and reusing
cytoplasm components. Moreover, autophagy regulates cell death under certain conditions …

Alzheimer's disease (AD) is the most common neurodegenerative disease, but it remains an
intractable condition. Its pathogenesis is predominantly attributed to the aggregation and …

High mobility group box 1 (HMGB1) is a nuclear protein that can bind to DNA and act as a co-
factor for gene transcription. When released into extracellular fluid, it plays a …