All serious fungal infections need appropriate antifungal therapy for successful patient
outcome. Only a few classes of antifungal drugs are available, so the emergence of …

Invasive fungal infections continue to appear in record numbers as the
immunocompromised population of the world increases, owing partially to the increased …

Abstract The Infectious Diseases Society of America (IDSA) Standards and Practice
Guidelines Committee collaborated with partner organizations to convene a panel of 10 …

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported
as major contributors to non-trauma deaths in the emergency departments worldwide. The …

Antifungal resistance represents a major clinical challenge to clinicians responsible for
treating invasive fungal infections due to the limited arsenal of systemically available …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Within the limited antifungal armamentarium, the azole antifungals are the most frequent
class used to treat Candida infections. Azole antifungals such as fluconazole are often …

The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …

Introduction Because of the high mortality of invasive fungal infections (IFIs), appropriate
exposure to antifungals appears to be crucial for therapeutic efficacy and safety. Materials …

Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum
concentrations, due in part to variant CYP2C19 alleles. Individuals who are CYP2C19 …