Direct‐acting antivirals for chronic hepatitis C

JC Jakobsen, EE Nielsen, J Feinberg… - Cochrane database …, 2017 - cochranelibrary.com
Background Millions of people worldwide suffer from hepatitis C, which can lead to severe
liver disease, liver cancer, and death. Direct‐acting antivirals (DAAs), eg sofosbuvir, are …

Current therapy for chronic hepatitis C: The role of direct-acting antivirals

G Li, E De Clercq - Antiviral research, 2017 - Elsevier
One of the most exciting developments in antiviral research has been the discovery of the
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …

Hepatitis C treatment: where are we now?

NJ Burstow, Z Mohamed, AI Gomaa… - … journal of general …, 2017 - Taylor & Francis
Chronic hepatitis C infection affects millions of people worldwide and confers significant
morbidity and mortality. Effective treatment is needed to prevent disease progression and …

Hepatitis C virus: viral quasispecies and genotypes

K Tsukiyama-Kohara, M Kohara - International journal of molecular …, 2017 - mdpi.com
Hepatitis C virus (HCV) mainly replicates in the cytoplasm, where it easily establishes
persistent infection, resulting in chronic hepatitis, liver cirrhosis, and hepatocellular …

Ribavirin revisited in the era of direct‐acting antiviral therapy for hepatitis C virus infection

JJ Feld, IM Jacobson, MS Sulkowski… - Liver …, 2017 - Wiley Online Library
Over the past two decades, ribavirin has been an integral component of treatment for
hepatitis C virus (HCV) infection, where it has been shown to improve the efficacy of …

Reaching hepatitis C virus elimination targets requires health system interventions to enhance the care cascade

N Scott, JS Doyle, DP Wilson, A Wade, J Howell… - International Journal of …, 2017 - Elsevier
Background Modelling suggests that achieving the World Health Organization's elimination
targets for hepatitis C virus (HCV) is possible by scaling up use of direct-acting antiviral …

Chronic hepatitis C burden and care cascade in Australia in the era of interferon‐based treatment

B Hajarizadeh, J Grebely, H McManus… - Journal of …, 2017 - Wiley Online Library
Abstract Background and Aim Interferon‐free direct‐acting antiviral regimens for hepatitis C
virus (HCV) infection have been recently available in Australia, beginning a new era in …

The association between race/ethnicity and the effectiveness of direct antiviral agents for hepatitis C virus infection

F Su, PK Green, K Berry, GN Ioannou - Hepatology, 2017 - journals.lww.com
Black race and Hispanic ethnicity were associated with lower rates of sustained virologic
response (SVR) to interferon‐based treatments for chronic hepatitis C virus infection …

Hepatitis C: efficacy and safety in real life

R Flisiak, J Pogorzelska… - Liver …, 2017 - Wiley Online Library
Interferon‐free combinations were registered in 2014 and 2015 for the treatment of chronic
HCV infection. As a result, real‐world experience has been gathered in the last year and this …

Hepatitis B and C

W Karnsakul, KB Schwarz - Pediatric Clinics, 2017 - pediatric.theclinics.com
Disclosure Statement: W. Karnsakul has had a relationship with Gilead as a sponsor for an
open-label, multicenter, multicohort, single-arm study to investigate the safety and efficacy of …