Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in
numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of …

Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the
alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There …

Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of
breathing, which coats and stabilizes the whole respiratory surface and possesses …

Pulmonary delivery of small interfering RNA (siRNA) has huge potential for the treatment of
a wide range of respiratory diseases. The ability of naked siRNA to transfect cells in the …

Once inhaled, nanoparticles (NPs) will first interact with lung surfactant system, which may
influence the colloidal aspects of NPs and consequently the toxic potential of NPs to …

Pulmonary surfactant is a crucial system to stabilize the respiratory air–liquid interface.
Furthermore, pulmonary surfactant has been proposed as an effective method for targeting …

The molecular-level interaction of levofloxacin with lung surfactant was investigated using
Langmuir monolayers and atomistic molecular dynamics (MD) simulations. In the simulation …

The adsorption of prednisolone on a lung surfactant model was successfully performed
using coarse grained molecular dynamics. The prednisolone coarse grained model was …

In this study, poly (lactic-co-glycolic acid)(PLGA) was used as a carrier to construct disulfiram-
loaded porous microparticle through the emulsion solvent evaporation method, using …

Lung-delivered polymer nanoparticles provoked dysfunction of the essential lung surfactant
system. A steric shielding of the nanoparticle surface with poloxamers could minimize the …