Background Due to the degeneracy of the genetic code, most amino acids can be encoded
by multiple synonymous codons. Synonymous codons naturally occur with different …

Codon optimization includes strategies in gene design engineering, which uses
synonymous codon changes to improve levels of protein production. Codon usage bias …

Messenger RNA (mRNA) translation and mRNA degradation are important determinants of
protein output, and they are interconnected. Previously, it was thought that translation of an …

The major drawback of the Baculovirus/Sf9 system for recombinant adeno-associated viral
(rAAV) manufacturing is that most of the Bac-derived rAAV vector serotypes, with few …

There is much debate on the adeno-associated virus (AAV) serotype that best targets
specific retinal cell types and the route of surgical delivery—intravitreal or subretinal. This …

The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) has been
included in the transgene cassette of adeno-associated virus (AAV) in several gene therapy …

Dysferlinopathy is an autosomal recessive muscular dystrophy characterized by the
progressive loss of motility that is caused by mutations throughout the DYSF gene. There are …

Purpose: Treatment of inherited retinal degenerations using adeno-associated viral (AAV)
vectors involves delivery by subretinal injection. In the latter stages, alteration of normal …

The green fluorescent proteins (GFPs) from Aequorea victoria, red fluorescent proteins
(RFPs) from coral or anemone, and their mutants have been widely used as marker and …

WO2017181162A1 - Methods of enhancing biological potency of baculovirus system-produced
recombinant adeno-associated virus - Google Patents WO2017181162A1 - Methods of …