Until recently, studies of natural killer (NK) cells in infection have focused almost entirely on
their role in viral infections. However, there is an increasing awareness of the potential for …

Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical
protection to malaria. New studies recently highlighted a central role for IFN-Is in …

Systemic tumour necrosis factor‐α (TNF‐α) may contribute to the pathogenesis of cerebral
malaria (CM) by promoting endothelial activation and parasite sequestration. However, less …

Background A mother's infection with placental malaria (PM) can affect her child's
susceptibility to malaria, although the mechanism remains unclear. The fetus acquires a …

Sex differences in the immune response and in infectious disease susceptibility have been
well described, although the mechanisms underlying these differences remain incompletely …

In this chapter we will critically review the body of evidence indicating that host immune
responses to parasitic infection also play a critical role in cerebral malaria pathogenesis, in …

NK cells are known to respond in vitro to P. falciparum-infected red blood cells (iRBCs),
although responses are highly heterogeneous between donors. Although their role during …

The concept of immunosuppression mediated by T cells is a remarkable example in the
history of science. The use of CD4 and CD25 as defining surface markers and the renaming …

Abstract Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple
stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene …

La sévérité du paludisme est influencée par des interactions complexes entre de nombreux
facteurs dont la génétique de l'hôte. Plusieurs études de liaison génétique menées dans …