Type 2 diabetes is a complex trait with both environmental and hereditary factors
contributing to the overall pathogenesis. One link between genes, environment, and disease …

In contrast to white adipose tissue (WAT), which stores energy in the form of triglycerides,
brown adipose tissue (BAT) dissipates energy by producing heat to maintain body …

The characterization of the epigenetic changes within the obesity-related adipose tissue will
provide new insights to understand this metabolic disorder, but adipose tissue is not easy to …

Monozygotic (MZ) twins share the same STR profile, demonstrating a practical problem in
forensic casework. DNA methylation has provided a suitable resource for MZ twin …

Background Human skeletal muscle stem cells are important for muscle regeneration.
However, the combined genome-wide DNA methylation and expression changes taking …

Introduction The prevalence of type 2 diabetes (T2D) and the metabolic syndrome (MetS) is
increasing and several studies suggested an involvement of DNA methylation in the …

Several studies have investigated the relationship between genetic variation and DNA
methylation with respect to type 2 diabetes, but it is unknown if DNA methylation is a …

Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later
life, supporting the 'developmental origins of health and disease'hypothesis. Epigenetic …

Aims/Hypothesis Failure in glucose response to insulin is a common pathology associated
with obesity. In this study, we analyzed the genome wide DNA methylation profile of visceral …

A genetic influence on methylation levels has been reported and methylation quantitative
trait loci (meQTL) have been identified in various tissues. The contribution of genetic and …