[HTML][HTML] Delivering safer immunotherapies for cancer
Cancer immunotherapy is now a powerful clinical reality, with a steady progression of new
drug approvals and a massive pipeline of additional treatments in clinical and preclinical …
drug approvals and a massive pipeline of additional treatments in clinical and preclinical …
Tailoring biomaterials for cancer immunotherapy: emerging trends and future outlook
Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) …
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
D Schmid, CG Park, CA Hartl, N Subedi… - Nature …, 2017 - nature.com
Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by
concentrating their action on the cells of interest. Because attempts to target tumors directly …
concentrating their action on the cells of interest. Because attempts to target tumors directly …
Enhancing adoptive cell therapy of cancer through targeted delivery of small-molecule immunomodulators to internalizing or noninternalizing receptors
Adoptive cell therapy (ACT) has achieved striking efficacy in B-cell leukemias, but less
success treating other cancers, in part due to the rapid loss of ACT T-cell effector function in …
success treating other cancers, in part due to the rapid loss of ACT T-cell effector function in …
Combination cancer therapy using chimeric antigen receptor-engineered natural killer cells as drug carriers
The therapeutic limitations of conventional chemotherapeutic drugs include chemo-
resistance, tumor recurrence, and metastasis. Numerous nanoparticle-based active …
resistance, tumor recurrence, and metastasis. Numerous nanoparticle-based active …
50th Anniversary Perspective: Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry
Biomaterials have been extensively used to leverage beneficial outcomes in various
therapeutic applications, such as providing spatial and temporal control over the release of …
therapeutic applications, such as providing spatial and temporal control over the release of …
Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells
Abstract Cytotoxic T-Lymphocytes (CTLs) kill pathogen-infected or transformed cells
following interaction of their T-cell receptors (TCRs) with foreign (eg virus-derived) peptides …
following interaction of their T-cell receptors (TCRs) with foreign (eg virus-derived) peptides …
Multifaceted immunomodulatory nanoliposomes: reshaping tumors into vaccines for enhanced cancer immunotherapy
YW Noh, SY Kim, JE Kim, S Kim, J Ryu… - Advanced Functional …, 2017 - Wiley Online Library
The design and synthesis of nanoparticles mimicking the key features in size, shape, and
surface molecular organization of biological objects that provide danger‐signals are …
surface molecular organization of biological objects that provide danger‐signals are …
Combinatorial drug delivery approaches for immunomodulation
JM Stewart, BG Keselowsky - Advanced drug delivery reviews, 2017 - Elsevier
Immunotherapy has been widely explored for applications to both augment and suppress
intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic …
intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic …
Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
KD Wittrup, BH Kwan, GAI Shuning - US Patent 9,844,582, 2017 - Google Patents
US9844582B2 - Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents -
Google Patents US9844582B2 - Synergistic tumor treatment with extended-PK IL-2 and …
Google Patents US9844582B2 - Synergistic tumor treatment with extended-PK IL-2 and …