Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Human abdominal aortic aneurysm (AAA) pathophysiology is not yet completely understood.
In conductance arteries, the insoluble extracellular matrix, synthesized by vascular smooth …

Rationale: Atherosclerosis and aneurysms are leading causes of mortality worldwide.
MicroRNAs (miRs) are key determinants of gene and protein expression, and atypical miR …

Objective—Sclerostin (SOST) has been identified as an important regulator of bone
formation; however, it has not been previously implicated in arterial disease. The aim of this …

Oxidative stress is a major hallmark of cardiovascular diseases although a causal link was
so far not proven by large clinical trials. However, there is a close association between …

The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …

Objective The purpose of this study was to establish a reliable, chronic model of abdominal
aortic aneurysm (AAA). Methods Wild-type 8-week-old C56BL/6 male mice (n= 120) were …

Abstract Aims Angiotensin II-infused ApoE-/-mice are a popular mouse model for preclinical
aneurysm research. Here, we provide insight in the often-reported but seldom-explained …

Objective—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic
aneurysm (AAA) formation is controversial. Others reported that systemic blockade of TGF-β …