Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and
contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal …

Background and Purpose: Natriuretic peptides have led the way as a diagnostic and
prognostic tool for the diagnosis and management of heart failure (HF). More recent …

Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in
2006, much has changed in the care for patients with HF. Over the past decade, the HF …

Diuretic Treatment in Heart Failure | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Organ injury and impairment are commonly observed in patients with acute heart failure
(AHF), and congestion is an essential pathophysiological mechanism of impaired organ …

Background Acute kidney injury (AKI) in the intensive care unit is associated with significant
mortality and morbidity. Objectives To determine and update previous recommendations for …

Background: Despite increased use of guideline-directed medical therapy (GDMT), some
patients with heart failure and reduced ejection fraction (HFrEF) remain at high risk for …

Background: The oral vasopressin-2 receptor antagonist tolvaptan causes aquaresis in
patients with volume overload, potentially facilitating decongestion and improving the …

Pediatric cardiomyopathies are rare diseases with an annual incidence of 1.1 to 1.5 per 100
000. Dilated and hypertrophic cardiomyopathies are the most common; restrictive …

Increased neurohumoral stimulation resulting in excessive sodium avidity and extracellular
volume overload are hallmark features of decompensated heart failure. Especially in case of …