Intracellular targeting mechanisms by antimicrobial peptides

CF Le, CM Fang, SD Sekaran - Antimicrobial agents and …, 2017 - Am Soc Microbiol
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …

Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria

JM Ageitos, A Sánchez-Pérez, P Calo-Mata… - Biochemical …, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short peptidic molecules produced by most living
creatures. They help unicellular organisms to successfully compete for nutrients with other …

Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017 - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Convergent evolution of defensin sequence, structure and function

TMA Shafee, FT Lay, TK Phan, MA Anderson… - Cellular and Molecular …, 2017 - Springer
Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are
produced by essentially all eukaryotes and are highly diverse in their sequences and …

Targeting a cell wall biosynthesis hot spot

A Müller, A Klöckner, T Schneider - Natural product reports, 2017 - pubs.rsc.org
Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very
effective target for antibiotic intervention, and numerous natural product inhibitors have been …

Cubosomes post-loaded with antimicrobial peptides: characterization, bactericidal effect and proteolytic stability

L Boge, A Umerska, N Matougui, H Bysell… - International journal of …, 2017 - Elsevier
Novel antibiotics, such as antimicrobial peptides (AMPs), have recently attended more and
more attraction. In this work, dispersed cubic liquid crystalline gel (cubosomes) was used as …

[HTML][HTML] Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

Z Li, R Mao, D Teng, Y Hao, H Chen, X Wang… - Scientific reports, 2017 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis,
which urgently demanding new drugs for treating infection. Two homologous insect CSαβ …

Computational tools for exploring sequence databases as a resource for antimicrobial peptides

WF Porto, AS Pires, OL Franco - Biotechnology advances, 2017 - Elsevier
Data mining has been recognized by many researchers as a hot topic in different areas. In
the post-genomic era, the growing number of sequences deposited in databases has been …

The heterologous expression strategies of antimicrobial peptides in microbial systems

T Deng, H Ge, H He, Y Liu, C Zhai, L Feng… - Protein Expression and …, 2017 - Elsevier
Antimicrobial peptides (AMPs) consist of molecules acting on the defense systems of
numerous organisms toward tumor and multiple pathogens, such as bacteria, fungi, viruses …

Human α-defensin 6: a small peptide that self-assembles and protects the host by entangling microbes

P Chairatana, EM Nolan - Accounts of chemical research, 2017 - ACS Publications
Conspectus Human α-defensin 6 (HD6) is a 32-residue cysteine-rich peptide that
contributes to innate immunity by protecting the host at mucosal sites. This peptide is …