Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

T Moriyama, YL Yang, R Nishii, H Ariffin… - Blood, The Journal …, 2017 - ashpublications.org
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …

Infectious complications in children with acute lymphoblastic leukemia treated with the Taiwan Pediatric Oncology Group protocol: A 16‐year tertiary single‐institution …

MJ Li, HH Chang, YL Yang, MY Lu… - Pediatric blood & …, 2017 - Wiley Online Library
Background Infection is a major complication in pediatric patients with acute lymphoblastic
leukemia during chemotherapy. In this study, the infection characteristics were determined …

Pediatric acute lymphoblastic leukemia with t(1;19)/TCF3‐PBX1 in Taiwan

HJ Yen, SH Chen, TY Chang, CP Yang… - Pediatric blood & …, 2017 - Wiley Online Library
Background In childhood acute lymphoblastic leukemia (ALL), t (1; 19)(q23; p13. 3) with
TCF3‐PBX1 fusion is one of the most frequent translocations. Historically, it has been …

Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL‐2002 study emphasizing optimal reinduction therapy and …

MJ Li, HC Liu, HJ Yen, TH Jaing, DT Lin… - Pediatric Blood & …, 2017 - Wiley Online Library
Background Reinduction therapy has improved the outcomes in children with acute
lymphoblastic leukemia (ALL). We sought to determine the optimal course (s) of reinduction …

Relapsed acute lymphoblastic leukemia of childhood

SH Lum, D Bonney, V Saha - Childhood Acute Lymphoblastic Leukemia, 2017 - Springer
Relapsed ALL remains a major therapeutic challenge with little improvements in outcome
over the last three-decades. In late relapsing BCP-ALL bone marrow disease, MRD has …