Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …

Aging is associated with a decline in mitochondrial function and the accumulation of
abnormal mitochondria. However, the precise mechanisms by which aging promotes these …

Current research has demonstrated that mitochondrial morphology, distribution, and function
are maintained by the balanced regulation of mitochondrial fission and fusion, and …

The current therapeutic strategy for the management of acute myocardial infarction (AMI) is
to return blood flow into the occluded coronary artery of the heart, a process defined as …

We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives
mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting …

Repetitive, calcium-mediated contractile activity renders cardiomyocytes critically dependent
on a sustained energy supply and adequate calcium buffering, both of which are provided …

Mitochondrial health is critically dependent on the ability of mitochondria to undergo
changes in mitochondrial morphology, a process which is regulated by mitochondrial …

Background Many cardioprotective pharmacological agents failed to exert their protective
effects in diabetic hearts subjected to myocardial ischemia/reperfusion (MI/R). Identify the …

Resveratrol is widely known for its antiaging properties and exerts cardiovascular protective
effects in different experimental models. The role of resveratrol in regulating mitochondrial …

The heart must function continuously as it is responsible for both supplying oxygen and
nutrients throughout the entire body, as well as for the transport of waste products to …