Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

The basal forebrain (BF) cholinergic system has an important role in attentive functions. The
cholinergic system can be activated by different inputs, and in particular, by orexin neurons …

Abstract Purpose of Review Hypertension is one of the most challenging health problems
inducing cerebrovascular disease and high percentage of death when associated with …

Orexin-A and-B neuropeptides are exclusively synthesized in hypothalamic neurons. These
have been implicated to play critical roles in the expression of various behavioral …

The neuropeptide orexin/hypocretin (OX), while largely transcribed within the hypothalamus,
is released throughout the brain to affect complex behaviors. Primarily through the …

The neuropeptide hypocretin is also commonly referred to as orexin, since its orexigenic
action was recognized early. Orexin/hypocretin (OX) neurons project widely throughout the …

Background Weight regain (WR) and symptoms of post–bariatric surgery hypoglycemia
(PBSH) are metabolic complications observed in a subset of postbariatric patients. Whether …

Glucose counter-regulatory dysfunction correlates with impaired activation of the
hypothalamic metabolic sensor adenosine 5′-monophosphate-activated protein kinase …

Pyroglutamylated RFamide peptide (QRFP) is a peptide expressed at highest levels in the
mediobasal hypothalamus, with lower levels of expression found in several tissues in the …

Nach wie vor fehlt es an Präventionsmöglichkeiten und effektiven und langfristig wirksamen
Therapien, mit denen eine dauerhafte Gewichtsnormalisierung und das Verhindern von …