Osteogenesis imperfecta (OI) is a skeletal dysplasia characterized by fragile bones and
short stature and known for its clinical and genetic heterogeneity which is now understood …

Ca2+ handling by the endoplasmic reticulum (ER) serves critical roles in controlling
pancreatic β cell function and becomes perturbed during the pathogenesis of diabetes. ER …

The discovery of the store-operated Ca 2+ entry (SOCE) phenomenon is tightly associated
with its recognition as a pathway of high (patho) physiological significance in the …

The mixing of mitochondrial DNA (mtDNA) from the donor cell and the recipient oocyte in
embryos and offspring derived from somatic cell nuclear transfer (SCNT) compromises …

Key points The role of trimeric intracellular cation (TRIC) channels is not known, although
evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms …

Reports of aberrant distribution for some nuclear envelope proteins in cells expressing a few
Emery–Dreifuss muscular dystrophy mutations raised the possibility that such protein …

Mammalian TRICs function as K+-permeable cation channels that provide counter ions for
Ca2+ handling in intracellular stores. Here we describe the structures of two prokaryotic …

During systole, Ca 2+ is released from the sarcoplasmic reticulum (SR) through ryanodine
receptors (RyRs) while, simultaneously, other ions (specifically K+, Mg 2+, and Cl−) provide …

Background Trimeric intracellular cation (TRIC) channels are crucial for Ca 2+ handling in
eukaryotes and are involved in K+ uptake in prokaryotes. Recent studies on the …

Astragaloside IV (AS-IV) is one of the active ingredients in Astragalus membrananceus
(Huangqi), a traditional Chinese medicine. The present study investigated the effects of AS …