Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …

The optic nerve and the cells that give origin to its 1.2 million axons, the retinal ganglion
cells (RGCs), are particularly vulnerable to neurodegeneration related to mitochondrial …

OPA1 is a GTPase that controls mitochondrial fusion, cristae integrity, and mtDNA
maintenance. In humans, eight isoforms are expressed as combinations of long and short …

Mitochondrial dysfunction commonly presents with ocular findings as a part of a systemic
disorder. These ophthalmic manifestations can be the first sign of a mitochondrial …

Replicative and chronological lifespan are two different modes of cellular aging.
Chronological lifespan is defined as the duration during which quiescent normal cells retain …

Wolfram syndrome (WS) is a progressive neurodegenerative disease characterized by early-
onset optic atrophy and diabetes mellitus, which can be associated with more extensive …

Dominant optic atrophy (DOA) and Leber hereditary optic neuropathy (LHON) are the two
most common inherited optic neuropathies encountered in clinical practice. This review …

Genetic disorders due to mitochondrial dysfunction are not uncommon and the majority of
these patients will have eye-related manifestations, including visual loss from the optic nerve …

Inherited optic neuropathies are a genetically diverse group of disorders mainly
characterized by visual loss and optic atrophy. Since the first recognition of Leber's …

Mycobacterium tuberculosis (M. tb) infection manifests into tuberculosis (TB) in a small
fraction of the infected population that comprises the TB susceptible group. Identifying the …