Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor
DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic …

Purpose Microsatellite instability (MSI) is a pattern of hypermutation that occurs at genomic
microsatellites and is caused by defects in the mismatch repair system. Mismatch repair …

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …

Abstract Genomics data from The Cancer Genome Atlas (TCGA) project has led to the
comprehensive molecular characterization of multiple cancer types. The large sample …

We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …

BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in
cancer studies. However, little is known about the transcriptomic profile of NAT, how it is …

Oesophageal cancers are prominent worldwide; however, there are few targeted therapies
and survival rates for these cancers remain dismal. Here we performed a comprehensive …