Current clinical treatment of Helicobacter pylori infection, the main etiological factor in the
development of gastritis, gastric ulcers, and gastric carcinoma, requires a combination of at …

The pharmaceutical development of new chemical entities can be hampered by their
solubility and/or dissolution limitations. Currently, these properties are characterised mostly …

Abstract Formulation development for preclinical studies is an essential part of the drug
discovery and development process in that it enables pharmacokinetics, efficacy, and safety …

Aim To evaluate an antibiotic inactivation strategy to protect the gut microbiome from
antibiotic‐mediated damage. Methods and Results SYN‐004 (ribaxamase) is an orally …

Despite many documented differences in gut physiology compared to humans, the beagle
dog has been successfully used as a preclinical model for assessing the relative …

The objective of this study was to develop an artificial stomach-duodenum (ASD) dissolution
model as an in vitro evaluation tool that would simulate the gastrointestinal physiology of …

The present study combines the theory and the experimental data to predict the changes on
intestinal bacterial populations during ingestion of beneficial probiotic bacteria. Our …

Drug solubility has a significant impact on bioavailability, therefore selecting and optimising
an appropriate drug formulation is imperative to the success of the program; moreover there …

Food and drug interaction or “food effect” has been broadly acknowledged to be a
complicated topic that deserves more research effort so that it can be more optimally …