To date, reperfusion with tissue plasminogen activator (tPA) remains the gold standard
treatment for ischemic stroke. However, when tPA is given beyond 4.5 hours of stroke onset …

Abstract Background/Aims: Enriched environment (EE) has been reported to exert
neuroprotective effect in animal models of ischemic stroke. However, the underlying …

Bryostatin 1, a potent activator of protein kinase C epsilon (PKCɛ), has been shown to
reverse synaptic loss and facilitate synaptic maturation in animal models of Alzheimer's …

Tissue plasminogen activator (tPA) thrombolysis remains the gold standard treatment for
ischemic stroke. A time-constrained therapeutic window, with the drug to be given within 4.5 …

We hypothesize that the primary mechanism for removal of glutamate from the extracellular
space is altered after traumatic brain injury (TBI). To evaluate this hypothesis, we initiated …

A shock-and-kill approach involving the simultaneous treatment of HIV-1–infected patients
with latency-reversing agents (LRAs) and combination antiretroviral therapy was proposed …

To study the influence of stachydrine hydrochloride on the inflammatory cytokines and tissue
morphology of the re-perfusion model of mice with repetitive cerebral ischemia and probe …

Global cerebral ischemia is a debilitating injury that damages the CA1 region of the
hippocampus, an area important for learning and memory. Protein kinase C epsilon (PKCɛ) …

Trichocolea tomentella (Trichocoleaceae) is a liverwort that has been found to grow in
contact with microbial rich environments such as humus, decayed woods and moist rocks …

Natural products are bioactive molecules produced across the tree of life and have been
used medicinally by humans for millennia. Isolation and characterization of these molecules …