The cell possesses the remarkable ability to perceive and process chemical and physical
stimuli, which in turn modulate cellular behavior. One of the great wonders about …

Despite the tremendous potential of peptide-based cancer vaccines, their efficacy has been
limited in humans. Recent innovations in tumour exome sequencing have signalled the new …

Molecular imaging has emerged as an indispensable technology in the development and
application of drug delivery systems. Targeted imaging agents report the presence of …

Docosahexaenoic acid (DHA) is uniquely concentrated in the brain, and is essential for its
function, but must be mostly acquired from diet. Most of the current supplements of DHA …

Codelivery of multiple chemotherapeutics has become a versatile strategy in recent cancer
treatment, but the antagonistic behavior of combined drugs limited their application. We …

High-density lipoproteins (HDLs) have multiple pleiotropic effects against arteriosclerosis.
Most are independent of the cholesterol mass within HDL particles. Yet, HDL cholesterol …

The development of drug resistance in cancer cells is one of the major obstacles to
achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin …

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy and has a 5-year survival
rate of< 35%. ACC cells require cholesterol for steroid hormone production, and this …

Synthetic high-density lipoprotein nanoparticles (sHDL) are a valuable class of
nanomedicines with established animal safety profile, clinical tolerability and therapeutic …

apoA-I, apoA-I mimetic peptides, and their lipid complexes or reconstituted high-density
lipoprotein (HDL) have been studied as treatments for various pathologies. However …