Mucociliary clearance (MCC) is the primary innate defense mechanism of the lung. The
functional components are the protective mucous layer, the airway surface liquid layer, and …

Background Dehydration of airway surface liquid (ASL) disrupts normal mucociliary
clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS) …

The initial pathological description of cystic fibrosis (CF) of the pancreas was reported in the
1930s (1, 2). Development of the sweat test (3) in the 1950s enabled clinical diagnosis and …

Airway submucosal glands (SMGs) are facultative stem cell niches for the surface
epithelium, but the phenotype of the SMG-derived progenitor cells remains unclear. In other …

High-frequency oscillatory ventilation (HFOV) has been proposed as gentle ventilation
strategy to prevent lung injury in the preterm infant. High-frequency jet ventilation leads to …

n order to decrease the morbidity and mortality induced by seasonal influenza outbreaks,
several hundred million vaccine doses are produced worldwide each year. The predominant …

The airway surface contains a number of important defense mechanisms to protect against
infection. Antimicrobials found in the thin layer of fluid lining the airways, the airway surface …

Cystic fibrosis (CF), the most common life-shortening autosomal recessive disorder in
Caucasians, results from mutations in the gene that encodes the cystic fibrosis …

Airway mucus is pivotal for physiological defense against invading particles, chemicals and
pathogenic microbes. However, any abnormality of mucins can cause altered airway …