Cervical cancer is the fourth most common malignancy diagnosed in women worldwide.
Nearly all cases of cervical cancer result from infection with the human papillomavirus, and …

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …

Immunotherapy has clinical activity in certain virally associated cancers. However, the tumor
antigens targeted in successful treatments remain poorly defined. We used a personalized …

Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A
unique aspect of human papillomavirus molecular biology involves dependence on the …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Lung squamous cell carcinoma (LSCC) pathogenesis remains incompletely understood,
and biomarkers predicting treatment response remain lacking. Here, we describe novel …

Background Safety and efficacy of pembrolizumab, a humanized programmed death 1
monoclonal antibody, was assessed in KEYNOTE-028, a multicohort, phase Ib trial for …

Aberrant activation of signaling through the RAS–RAF–MEK–ERK (MAPK) pathway is
implicated in numerous cancers, making it an attractive therapeutic target. Although BRAF …

Purpose To provide resource-stratified, evidence-based recommendations on the secondary
prevention of cervical cancer globally. Methods ASCO convened a multidisciplinary …