Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts
(CAFs), to remodel their extracellular matrix (ECM) and promote invasive tumor growth. Two …

Purpose Cilengitide is a potent and selective inhibitor of the integrins αvβ3 and αvβ5. The
primary objective of this phase I clinical trial was to establish the maximum tolerated dose …

Otitis media (OM), inflammation of the middle ear (ME), is a common cause of conductive
hearing impairment. Despite the importance of the disease, the aetiology of chronic and …

Aims/hypothesis Diabetes promotes cerebral neovascularisation via increased vascular
endothelial growth factor (VEGF) angiogenic signalling. Roundabout-4 (ROBO4) protein is …

The nanoscale materials properties of bone apatite crystals have been implicated in breast
cancer bone metastasis and their interactions with extracellular matrix proteins are likely …

When designing an implantable material, we should consider how the material's microscale
structure affects cells that contact the material. Cells respond to microscale structure through …