Protein homeostasis, or proteostasis, has an important regulatory role in cellular function.
Protein quality control mechanisms, including protein folding and protein degradation …

RGG/RG domains are the second most common RNA binding domain in the human
genome, yet their RNA-binding properties remain poorly understood. Here, we report a …

Certain forms of amyotrophic lateral sclerosis (ALS) are associated with an altered
compartmentalization of FUS and its aggregation in the cytoplasm of motoneurons. FUS is a …

Five structurally and functionally different proteins, an enzyme superoxide dismutase 1
(SOD1), a TAR-DNA binding protein-43 (TDP-43), an RNA-binding protein FUS, a cofilin …

Antisense oligonucleotides (ASOs) are versatile tools that can regulate multiple steps of
RNA biogenesis in cells and living organisms. Significant improvements in delivery, potency …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that is clinically
characterized by progressive muscle weakness and impaired voluntary movement due to …

FUS, an RNA-binding protein (RBP), is mutated or abnormally regulated in
neurodegenerative disorders. FUS regulates various aspects of RNA metabolisms. FUS …

Enzymes and structural proteins dominated thinking about protein structure and function for
most of the twentieth century. In recent decades, however, we have begun to appreciate the …

При некоторых формах бокового амиотрофического склероза наблюдается
нарушение компарт-ментализации белка FUS и его агрегация в цитоплазме …

Recent developments in the comprehensive identification of the RNA-binding protein (RBP)
repertoire has accelerated discovery of new RBPs. According to these studies, 20% of both …