Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Background Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive
pathways in human peripheral and central nervous system and its receptors are also …

Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …

El dolor es la principal causa de consulta médica. El costo económico del dolor es brutal.
Tan solo en Estados Unidos, en el 2010, se estiman costos totales entre 560y 635 billones …

Serotonergic mechanisms play a central role in migraine pathology. However, the region-
specific effects of serotonin (5-HT) mediated via multiple types of receptors in the nociceptive …

Neuropathic pain can have a major effect on quality of life but current therapies are often
inadequate. Growing evidence suggests that neuropathic pain induced by nerve damage is …

The high worldwide prevalence of osteoporosis means it is considered a serious public
health concern, possibly leading to physical disability and an increased mortality rate …

Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant
regeneration. Common etiologies of neuropathy include chronic illnesses and medication …

Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Before the discovery of the endogenous opioid system in the 1970s, opioids were
understood only through the lens of opioid drug effects. Opium produced sleep, pain relief …