Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model

A Giralt, V Brito, Q Chevy, C Simonnet, Y Otsu… - Nature …, 2017 - nature.com
The structure and function of spines and excitatory synapses are under the dynamic control
of multiple signalling networks. Although tyrosine phosphorylation is involved, its regulation …

Induced pluripotent stem cell-derived neural stem cell transplantations reduced behavioral deficits and ameliorated neuropathological changes in YAC128 mouse …

A Al-Gharaibeh, R Culver, AN Stewart… - Frontiers in …, 2017 - frontiersin.org
Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by
neuronal loss and motor dysfunction. Although there is no effective treatment, stem cell …

Silver nanoparticles modified with thiomalic acid as a colorimetric probe for determination of cystamine

S Mohammadi, G Khayatian - Microchimica Acta, 2017 - Springer
The authors describe a colorimetric method for highly selective determination of cystamine
using silver nanoparticles capped with thiomalic acid (TMA-AgNPs). The TMA-AgNPs exhibit …

Varenicline improves motor and cognitive deficits and decreases depressive-like behaviour in late-stage YAC128 mice

AL McGregor, G D'Souza, D Kim, MD Tingle - Neuropharmacology, 2017 - Elsevier
Objective Studies in the post mortem human brain and in genetic mouse model suggest that
dysfunctional cholinergic neurotransmission, through a loss of agonist rather than receptors …

Natural products against Huntington's disease (HD): implications of neurotoxic animal models and transgenics in preclinical studies

A Dey - Neuroprotective Natural Products: Clinical Aspects and …, 2017 - Wiley Online Library
Huntington's disease (HD) is a neurological disorder characterized by abnormal body
movements (chorea) associated with cognitive and motor dysfunctions, neuropsychiatric …

Huntington Disease

EH Kim, N Mehrabi, LJ Tippett, HJ Waldvogel… - The Cerebral Cortex in …, 2017 - Elsevier
This chapter focuses on the involvement of the cerebral cortex in Huntington disease, with
special emphasis on the link between cortical pathology and variable clinical manifestations …

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

A Giralt Torroella, V Brito, Q Chevy… - … , 2017, vol. 8, num …, 2017 - diposit.ub.edu
The structure and function of spines and excitatory synapses are under the dynamic control
of multiple signalling networks. Although tyrosine phosphorylation is involved, its regulation …

Role of lysine deacetylases on transcription regulation and mitochondrial function in Huntington's disease

LC Naia - 2017 - estudogeral.uc.pt
Huntington's disease (HD) is a neurodegenerative disorder that gradually affects memory,
cognitive skills and normal movements of the affected individuals and for which no disease …