Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory
diseases. Both diseases have incompletely distinct pathophysiology, clinical manifestation …

Gout is a disease characterized by the deposition of monosodium urate (MSU) crystals in the
joints. Continuous gout episodes may lead to unresolved inflammatory responses and tissue …

Inflammation resolution is an active process that functions to restore tissue homeostasis. The
participation of the plasminogen (Plg)/plasmin (Pla) system in the productive phase of …

Chronic respiratory diseases affect millions of people every day. According to the World
Health Organization estimates,~ 235 million people suffer from asthma,~ 64 million suffer …

Gout is a self‐limited inflammatory disease caused by deposition of monosodium urate
(MSU) crystals in the joints. Resolution of inflammation is an active process leading to …

The lifespan of neutrophils is plastic and highly responsive to factors that regulate cellular
survival. Defects in neutrophil number and survival are common to both hematologic …

Annexin A1 (AnxA1) is a glucocorticoid-regulated protein known for its anti-inflammatory and
pro-resolving effects. We have shown previously that the cAMP-enhancing compounds …

Defective resolution of inflammation may be crucial for the initiation and development of
chronic inflammatory diseases, such as arthritis. Therefore, it has been suggested that …

Roflumilast, a potent and selective inhibitor of phosphodiesterase-4 (PDE4), has been used
in treatment of COPD. PDE4 inhibitor is associated with inhibition of chronic airway …

Phosphodiesterases (PDEs) may modulate inflammatory pathways, but PDE expression is
poorly documented in humans with sepsis. Using quantitative PCR on whole blood …