The mitochondrial carrier system (MCS) transports small molecules between mitochondria
and the cytoplasm. It is integral to the core mitochondrial function to regulate cellular …

Oligomerization of membrane proteins in response to lipid binding has a critical role in many
cell-signalling pathways but is often difficult to define or predict. Here we report the …

The rational (de novo) design of membrane-spanning proteins lags behind that for water-
soluble globular proteins. This is due to gaps in our knowledge of membrane-protein …

Transporters shuttle molecules across cell membranes by alternating among distinct
conformational states. Fundamental questions remain about how transporters transition …

Sugar Will Eventually be Exported Transporters (SWEETs) are recently identified sugar
transporters that can discriminate and transport di-or monosaccharides across a membrane …

Sugars Will Eventually be Exported Transporter (SWEET) and SemiSWEET are recently
characterized families of sugar transporters in eukaryotes and prokaryotes, respectively …

Symbiotic nitrogen fixation in legumes contributes greatly to the global nitrogen cycle on the
earth. In nodules, resident rhizobia supply nitrogen nutrient fixed from atmospheric N2 to the …

Mass spectrometry (MS) applications for intact protein complexes typically require
electrospray (ES) ionization and have not been achieved via direct desorption from surfaces …

Alterations in mitochondrial function contribute to diabetic cardiomyopathy. We have
previously shown that heart mitochondrial proteins are hyperacetylated in OVE26 mice, a …

Highlights•Flucs are highly selective fluoride channels that protect microbes against
cytoplasmic accumulation of toxic fluoride ion.•Flucs are found as dual-topology …