Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and …

J Duncombe, A Kitamura, Y Hase, M Ihara… - Clinical …, 2017 - portlandpress.com
Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Extracellular matrix inflammation in vascular cognitive impairment and dementia

GA Rosenberg - Clinical science, 2017 - portlandpress.com
Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic
manifestations of vascular disease related to large vessel strokes and small vessel disease …

Aortic stiffness, increased white matter free water, and altered microstructural integrity: a continuum of injury

P Maillard, GF Mitchell, JJ Himali, A Beiser, E Fletcher… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Previous reports from the Framingham Heart Study have
identified cross-sectional associations of arterial stiffness, as reflected by carotid–femoral …

Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms

A Joutel, H Chabriat - Clinical Science, 2017 - portlandpress.com
Cerebral small vessel diseases (SVDs) are a leading cause of age and hypertension-related
stroke and dementia. The salient features of SVDs visible on conventional brain magnetic …

Validation of a regression technique for segmentation of white matter hyperintensities in Alzheimer's disease

M Dadar, TA Pascoal, S Manitsirikul… - IEEE transactions on …, 2017 - ieeexplore.ieee.org
Segmentation and volumetric quantification of white matter hyperintensities (WMHs) is
essential in assessment and monitoring of the vascular burden in aging and Alzheimer's …

Advanced neuroimaging of cerebral small vessel disease

GW Blair, MV Hernandez, MJ Thrippleton… - … treatment options in …, 2017 - Springer
Opinion statement Cerebral small vessel disease (SVD) is characterised by damage to deep
grey and white matter structures of the brain and is responsible for a diverse range of clinical …

Imaging cerebrovascular alterations in experimental models of ageing and vascular cognitive impairment

J Duncombe - 2017 - era.ed.ac.uk
Vascular cognitive impairment describes a heterogeneous condition in which cognitive
decline is precipitated by underlying cerebrovascular dysfunction. Ageing, as well as …

[图书][B] Progressive Slowing of the Cerebrovascular Response in the Temporal and Parietal Cortex of Patients with Alzheimer's Disease and Mild Cognitive Impairment

KR Holmes - 2017 - search.proquest.com
There is accumulating evidence that neurovascular dysfunction plays a major role in
Alzheimer's disease (AD). Recent investigations now suggest that cerebrovascular reactivity …

[PDF][PDF] Advanced Neuroimaging of Cerebral Small Vessel

GW Blair, MV Hernandez, MJ Thrippleton, FN Doubal… - pure.ed.ac.uk
Cerebral small vessel disease (SVD) is a condition resulting from damage to the cerebral
microcirculation and predominantly affects the blood supply and tissue of the deep white …