Magnetic sensing platform technologies for biomedical applications

G Lin, D Makarov, OG Schmidt - Lab on a Chip, 2017 - pubs.rsc.org
Detection and quantification of a variety of micro-and nanoscale entities, eg molecules, cells,
and particles, are crucial components of modern biomedical research, in which biosensing …

Splanchnic vein thrombosis in myeloproliferative neoplasms: pathophysiology and molecular mechanisms of disease

J How, A Zhou, ST Oh - Therapeutic advances in …, 2017 - journals.sagepub.com
Myeloproliferative neoplasms (MPNs) are the most common underlying prothrombotic
disorder found in patients with splanchnic vein thrombosis (SVT). Clinical risk factors for …

[HTML][HTML] Ruxolitinib reduces JAK2 p.V617F allele burden in patients with polycythemia vera enrolled in the RESPONSE study

AM Vannucchi, S Verstovsek, P Guglielmelli… - Annals of …, 2017 - Springer
In patients with polycythemia vera (PV), an elevated JAK2 p. V617F allele burden is
associated with indicators of more severe disease (eg, leukocytosis, splenomegaly, and …

The efficacy and safety of continued hydroxycarbamide therapy versus switching to ruxolitinib in patients with polycythaemia vera: a randomized, double‐blind, double …

R Mesa, AM Vannucchi, A Yacoub… - British journal of …, 2017 - Wiley Online Library
The randomized, double‐blind, double‐dummy, phase 3b RELIEF trial evaluated
polycythaemia vera (PV)‐related symptoms in patients who were well controlled with a …

Safety and efficacy of ruxolitinib in splanchnic vein thrombosis associated with myeloproliferative neoplasms

L Pieri, C Paoli, U Arena, F Marra, F Mori… - American journal of …, 2017 - Wiley Online Library
Splanchnic vein thrombosis (SVT) is one of the vascular complications of myeloproliferative
neoplasms (MPN). We designed a phase 2 clinical trial to evaluate safety and efficacy of …

Benefits and risks of antithrombotic therapy in essential thrombocythemia: a systematic review

DK Chu, CM Hillis, DP Leong, SS Anand… - Annals of Internal …, 2017 - acpjournals.org
Background: Patients with essential thrombocythemia (ET) are at high risk for both
thrombosis and hemorrhage. Purpose: To evaluate the risks and benefits of antithrombotic …

The clonal origins of leukemic progression of myelodysplasia

T Kim, MS Tyndel, HJ Kim, JS Ahn, SH Choi, HJ Park… - Leukemia, 2017 - nature.com
The genetics behind the progression of myelodysplasia to secondary acute myeloid
leukemia (sAML) is poorly understood. In this study, we profiled somatic mutations and their …

[HTML][HTML] The role of the extracellular matrix in primary myelofibrosis

O Leiva, SK Ng, S Chitalia, A Balduini, S Matsuura… - Blood cancer …, 2017 - nature.com
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal
proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) …

[HTML][HTML] Efficacy of ALK5 inhibition in myelofibrosis

L Yue, M Bartenstein, W Zhao, WT Ho, Y Han… - JCI insight, 2017 - ncbi.nlm.nih.gov
Myelofibrosis (MF) is a bone marrow disorder characterized by clonal myeloproliferation,
aberrant cytokine production, extramedullary hematopoiesis, and bone marrow fibrosis …

[HTML][HTML] Clinical significance of circulating microparticles in Ph-myeloproliferative neoplasms

W Zhang, J Qi, S Zhao, W Shen, L Dai… - Oncology …, 2017 - spandidos-publications.com
Microparticles (MPs) are small membrane vesicles that are classified into subcategories
based on their origin, such as platelet‑derived MPs (PMPs), endothelial MPs (EMPs), red …