Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Hypersialylation of tumor cell surface proteins along with a marked upregulation of
sialyltransferase (ST) activity is a wellestablished hallmark of cancer. Due to the critical role …

The activation of synaptic N-methyl-d-aspartate-receptors (NMDARs) is crucial for induction
of synaptic plasticity and supports cell survival, whereas activation of extrasynaptic NMDARs …

Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule
(NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains …

ST8SIA2 is a polysialyltransferase that attaches polysialic acid to the glycoproteins NCAM1
and CADM1. Polysialylation is involved in brain development and plasticity. ST8SIA2 is a …

脳に特異的な糖鎖エピト恁驻扦るポリシアル酸はシアル酸の直鎖状のホモポリマ恧扦り,
大きな負電荷とかさ高い排除体積によって, 細胞接着を負に制御する反接着機能分子として働く …