Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …

Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of
Alzheimer's disease (AD). These include the earliest known cytopathology that is specific to …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

Mutations in amyloid β precursor protein (APP) gene alter APP processing, either causing
familial Alzheimer9s disease (AD) or protecting against dementia. Under normal conditions …

Neurotoxic amyloid-β peptides (Aβ) are major drivers of Alzheimer's disease (AD) and are
formed by sequential cleavage of the amyloid precursor protein (APP) by β-secretase …

Abstract γ‐Secretase is a four‐component membrane‐embedded aspartyl protease involved
in the final cleavage step of the amyloid precursor protein (APP) to generate the amyloid‐β …

Aberrant aggregation into oligomers and amyloid fibrils is a universal process shared across
many proteins associated with human diseases. Alzheimer's disease (AD) is characterized …

The success of anti-amyloid β-protein passive immunotherapy on patients with mild
cognitive declines supports the amyloid cascade hypothesis and indicates the potential of …

Alzheimers disease (AD) biomarkers that can detect and track disease progression at its
earliest stages to aid the critical search for a disease modifying therapy is much needed …

Inflammation plays a major role in Alzheimer's disease (AD). Investigating how specific
mediators of inflammation contribute to neurodegeneration in AD is crucial. Our studies …