Twenty‐five genome‐wide association studies (GWAS) of asthma were published between
2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies …

Chromosome 17q21 contains a cluster of genes including ORMDL3 and GSDMB, which
have been highly linked to asthma in genome-wide association studies. ORMDL3 is …

Highlights•Exposure to farm environments protects against asthma by activating innate
pathways.•Children raised in a protective farm environment have distinct immune cell …

Epidemiologic studies support that at least part of the risk of chronic diseases in childhood
and even adulthood may have an in utero origin, and the placenta is a key organ that plays …

Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim
to identify genetic variants that confer susceptibility to asthma in Puerto Ricans. We …

Objective We studied the role of the NC_000017. 10: g. 38051348A> G (rs8067378) single
nucleotide polymorphism (SNP) located 9.5 kb downstream of gasdermin B (GSDMB), in the …

Australia. E-mail: sarah. vreugde@ adelaide. edu. au. Disclosure of potential conflict of
interest: S. Moraitis, AJ Psaltis, P.-J. Wormald, S. Vreugde, and S. McColl are employed by …

Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory
polymorphisms that influence expression levels of all five protein-coding genes in the …

Background Gene expression changes in the structural cells of the airways are thought to
play a role in the development of asthma and airway hyperresponsiveness. This includes …

Prenatal phthalate exposure associates with low regulatory T-cell numbers and atopic
dermatitis in early childhood: Results from human patients with allergic asthma following …