Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …

Crohn's disease and ulcerative colitis, the 2 major forms of inflammatory bowel disease
(IBD) in humans, arise in genetically predisposed individuals because of an abnormal …

Purpose The dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive-
combined immunodeficiency whose clinical spectra include recurrent infections …

Background Low dose IL-2 can restore the function of T and NK cells from Wiskott-Aldrich
(WAS) patients. However, the safety of in vivo IL-2 in WAS is unknown. Objectives A phase-I …

Abstract Background The Wiskott–Aldrich syndrome protein (WASp) family of actin-
nucleating factors are present in the cytoplasm and in the nucleus. The role of nuclear WASp …

Alterations in the skin can give the astute clinician insight into the inner workings of the
immune system that may otherwise remain invisible. The skin can be altered in numerous …

Wiskott‑Aldrich syndrome (WAS) is a rare X‑linked recessive immunodeficiency disorder,
characterized by thrombocytopenia, small platelets, eczema and recurrent infections …

Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency caused by mutations in the
gene encoding the hematopoietic-specific WAS protein (WASp). WAS is frequently …

The actin cytoskeleton provides mechanical support for cells and generates forces to drive
cell shape changes and cell migration in morphogenesis. Molecular understanding of actin …

Plusieurs populations de cellules immunitaires possèdent une activité cytotoxique
permettant l'élimination de cellules altérées. Cette fonction cellulaire est ainsi déterminante …