Prodrugs of Pyrazolo[3,4-d]pyrimidines: From Library Synthesis to Evaluation as Potential Anticancer Agents in an Orthotopic Glioblastoma Model
G Vignaroli, G Iovenitti, C Zamperini… - Journal of Medicinal …, 2017 - ACS Publications
Pyrazolo [3, 4-d] pyrimidines are potent protein kinase inhibitors with promising antitumor
activity but suboptimal aqueous solubility, consequently worth being further optimized …
activity but suboptimal aqueous solubility, consequently worth being further optimized …
[HTML][HTML] Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes
ΑS Liossi, D Ntountaniotis, TF Kellici… - … et Biophysica Acta (BBA …, 2017 - Elsevier
The interactions of irbesartan (IRB) and irbesartan–2-hydroxypropyl-β-cyclodextrin (HP-β-
CD) complex with dipalmitoyl phosphatidylcholine (DPPC) bilayers have been explored …
CD) complex with dipalmitoyl phosphatidylcholine (DPPC) bilayers have been explored …
Synthesis, EGFR Inhibition and Anti-cancer Activity of New 3, 6-dimethyl-1-phenyl-4-(substituted-methoxy) pyrazolo [3, 4-d] pyrimidine Derivatives
RB Bakr, A BM Mehany… - Anti-Cancer Agents in …, 2017 - ingentaconnect.com
Background: Several pyrazolo [3, 4-d] pyrimidine derivatives have been reported as anti-
cancer agents via acting as EGFR inhibitors, mammalian target of rapamycin (mTOR) …
cancer agents via acting as EGFR inhibitors, mammalian target of rapamycin (mTOR) …
A novel multi-tiered experimental approach unfolding the mechanisms behind cyclodextrin-vitamin inclusion complexes for enhanced vitamin solubility and stability
MC Braithwaite, P Kumar, YE Choonara… - International Journal of …, 2017 - Elsevier
This study was conducted to provide a mechanistic account for understanding the synthesis,
characterization and solubility phenomena of vitamin complexes with cyclodextrins (CD) for …
characterization and solubility phenomena of vitamin complexes with cyclodextrins (CD) for …
Physico-chemical and biological evaluation of flavonols: Fisetin, quercetin and kaempferol alone and incorporated in beta cyclodextrins
D Corina, F Bojin, R Ambrus, D Muntean… - Anti-Cancer Agents …, 2017 - ingentaconnect.com
Background: Fisetin, quercetin and kaempferol are among the important representatives of
flavonols, biological active phytocomounds, with low water solubility. Objective: To evaluate …
flavonols, biological active phytocomounds, with low water solubility. Objective: To evaluate …
Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of Imidazolone Fused Pyrazolo [1, 5‐a] pyrimidine Derivatives
A novel series of imidazolone fused pyrazolo [1, 5‐a] pyrimidine derivatives has been
designed and synthesized using a convergent approach, and the structures of these …
designed and synthesized using a convergent approach, and the structures of these …
Differentially activated Src kinase in chemo‐naïve human primary osteosarcoma cells and effects of a Src kinase inhibitor
The therapeutic treatment of osteosarcoma (OS), a rare malignant teenage cancer of the
skeletal system, still represents a great challenge as patient survival after conventional …
skeletal system, still represents a great challenge as patient survival after conventional …