Using biomaterials to rewire the process of wound repair
A Stejskalová, BD Almquist - Biomaterials science, 2017 - pubs.rsc.org
Wound healing is one of the most complex processes that our bodies must perform. While
our ability to repair wounds is often taken for granted, conditions such as diabetes, obesity …
our ability to repair wounds is often taken for granted, conditions such as diabetes, obesity …
Sulfated glycopeptide nanostructures for multipotent protein activation
Biological systems have evolved to utilize numerous proteins with capacity to bind
polysaccharides for the purpose of optimizing their function. A well-known subset of these …
polysaccharides for the purpose of optimizing their function. A well-known subset of these …
Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer
L Formisano, KM Stauffer, CD Young, NE Bhola… - Clinical Cancer …, 2017 - AACR
Purpose: FGFR1 amplification occurs in approximately 15% of estrogen receptor–positive
(ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification …
(ER+) human breast cancers. We investigated mechanisms by which FGFR1 amplification …
Heparan sulfate microarray reveals that heparan sulfate–protein binding exhibits different ligand requirements
Heparan sulfates (HS) are linear sulfated polysaccharides that modulate a wide range of
physiological and disease-processes. Variations in HS epimerization and sulfation provide …
physiological and disease-processes. Variations in HS epimerization and sulfation provide …
Uncoupling the mitogenic and metabolic functions of FGF1 by tuning FGF1-FGF receptor dimer stability
The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose
homeostasis has expanded the functions of this classically known mitogen. To dissect the …
homeostasis has expanded the functions of this classically known mitogen. To dissect the …
Mimicking the bioactivity of fibroblast growth factor-2 using supramolecular nanoribbons
CM Rubert Pérez, Z Álvarez, F Chen… - ACS biomaterials …, 2017 - ACS Publications
Fibroblast growth factor (FGF-2) is a multifunctional growth factor that has pleiotropic effects
in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an …
in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an …
Perlecan and vascular endothelial growth factor-encoding DNA-loaded chitosan scaffolds promote angiogenesis and wound healing
The repair of dermal wounds, particularly in the diabetic population, poses a significant
healthcare burden. The impaired wound healing of diabetic wounds is attributed to low …
healthcare burden. The impaired wound healing of diabetic wounds is attributed to low …
Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish
DM Leerberg, K Sano, BW Draper - PLoS genetics, 2017 - journals.plos.org
The vertebrate ovary and testis develop from a sexually indifferent gonad. During early
development of the organism, primordial germ cells (the gamete lineage) and somatic …
development of the organism, primordial germ cells (the gamete lineage) and somatic …
Heparan sulfate domains required for fibroblast growth factor 1 and 2 signaling through fibroblast growth factor receptor 1c
A small library of well defined heparan sulfate (HS) polysaccharides was
chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast …
chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast …
Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases
Y Xu, AF Moon, S Xu, JM Krahn, J Liu… - ACS chemical …, 2017 - ACS Publications
Heparan sulfate (HS) is a sulfated polysaccharide exhibiting essential physiological
functions. HS 6-O-sulfotransferase (6-OST) transfers a sulfo group to the 6-OH position of …
functions. HS 6-O-sulfotransferase (6-OST) transfers a sulfo group to the 6-OH position of …