Zebrafish are an excellent animal model for research on vertebrate development and human
diseases. Sophisticated genetic tools including large-scale mutagenesis methodology make …

Cyclic-GMP is a second messenger in phototransduction, a G-protein signaling cascade that
conveys photon absorption by rhodopsin to a change in current at the rod photoreceptor …

Modern agriculture is facing significant challenges due to the high complexity of field
conditions caused not only by currently ongoing global climatic change but also by stress …

Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have
been shown to contribute to photoreceptor death in models of inherited retinal degenerative …

Thyroid hormone (TH) signaling regulates cell proliferation, differentiation, and metabolism.
Recent studies have implicated TH signaling in cone photoreceptor viability. Using mouse …

To date, most studies involving in vivo electroretinography in mice are performed on steady
state adapted animals. In this study, we focused on the dynamics of adaptation to high and …

Purpose The apoptotic mechanisms responsible for secondary cone death in retinitis
pigmentosa (RP) remain largely unknown. The cone-enriched apoptotic protease caspase-7 …

The cone photoreceptor-specific cyclic nucleotide-gated (CNG) channel is indispensable for
cone function. Cones are essential for daylight vision and visual acuity. Mutations in the …