Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting
states. However, the mechanisms responsible for the regulation of pancreatic α cell mass …

Objectives Mutations in KCNJ11 are the most common cause of permanent neonatal
diabetes mellitus (NDM). Approximately 25% of patients have obvious neurological …

Overexpression of bovine growth hormone (bGH) in transgenic (PEPCK-bGH) mice induces
resistance to insulin, which is compensated by a major increase in insulin levels. In these …

Parkinson's disease (PD) is not only associated with degeneration of dopaminergic
(DAergic) neurons in the Substantia Nigra, but also with profound loss of noradrenergic …

Objective Potassium channels of the ATP-sensitive family (K ATP channel) are inhibited by
increase in intracellular ATP. Electrophysiological studies have demonstrated that the …

Anoxic depolarization (AD) is an acute event evoked by brain ischemia, involving a profound
loss of cell membrane potential and swelling that spreads over susceptible parts of the gray …

Selenium (Se) is an antioxidant trace element that is important for normal brain function. Se
is incorporated into selenoproteins, a family of proteins with multiple functions that include …

Midbrain dopaminergic (DA) neurons play several key functions in the brain such as the
processing of salient information but are also associated with the emergence of pathologies …

The overall goal of this thesis is to develop a better understanding of the brain's regulation of
appetite, ie the hypothalamic regulation of hunger and satiety signals. The correct regulation …