The E3 ligase CHIP mediates p21 degradation to maintain radioresistance

K Biswas, S Sarkar, K Du, DL Brautigan, T Abbas… - Molecular Cancer …, 2017 - AACR
Lung cancer resists radiotherapy, making it one of the deadliest forms of cancer. Here, we
show that human lung cancer cell lines can be rendered sensitive to ionizing radiation (IR) …

Target/signalling pathways of natural plant-derived radioprotective agents from treatment to potential candidates: a reverse thought on anti-tumour drugs

KL Yun, ZY Wang - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Radiation damage can occur in nuclear power plant workers when physical protections fail,
which results in nuclear leakage through the protective layers. Alternatively, workers may be …

Protective effect of amifostine on busulfan induced DNA damage in human hepatoma cells

N Ghassemi-Barghi, M Etebari… - Toxicology …, 2017 - Taylor & Francis
Busulfan is one of the most effective chemotherapeutic agents used for the treatment of
chronic myeloid leukemia. However, as a bifunctional alkylating agent, during clinical use …

[HTML][HTML] PAFR selectively mediates radioresistance and irradiation-induced autophagy suppression in prostate cancer cells

B Yao, B Liu, L Shi, X Li, C Ren, M Cai, W Wang, J Li… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Platelet-activating factor receptor (PAFR) promotes tumorigenesis, angiogenesis and
metastasis. Here, we defined the PAFR as a yielding new inhibiting target to selectively …

Protection and sensitization of human cells to proton radiation by cerium oxide nanoparticles

NB Carlson - 2017 - thescholarship.ecu.edu
In radiation therapy for the treatment of cancer, there is demand for novel approaches that
will improve tumor cell killing while protecting healthy tissue. One such approach that has …

[PDF][PDF] Radioprotection by combination of DNA binding antioxidants and aminothiol radical scavengers

J Smith - 2017 - minerva-access.unimelb.edu.au
The unavoidable irradiation of normal tissue during cancer radiotherapy can lead to serious
dose limiting side-effects. For example, radiation-induced oral mucositis associated with …