Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity
epidemic, which is unveiling a myriad of comorbidities associated with excess adipose …

Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin
resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP …

Insulin resistance results from an intricate interaction between genetic make-up and
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …

Context: Vitamin D accumulates in adipose tissue (AT), and vitamin D deficiency is frequent
in obesity. Objective: We hypothesize that trafficking of vitamin D is altered in dysfunctional …

Purpose The primary objective of the present study was to examine the association between
branched chain and aromatic amino acid profiles (BCAA and AAA respectively) and the …

Three Akt isoforms, encoded by 3 separate genes, are expressed in mammals. While the
roles of Akt1 and Akt2 in metabolism are well established, it is not yet known whether Akt3 …

Insulin resistance is a major risk factor for many diseases. However, its underlying
mechanism remains unclear in part because it is triggered by a complex relationship …

Insulin resistance results from an intricate interaction between genetic make-up and
environment, and thus may be orchestrated by epigenetic mechanisms like DNA …

The thesis entitled Exercise and Adipose Tissue GLUT4 has been submitted in total
fulfilment of the degree of Doctor of Philosophy and comprises only my original, previously …