This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants
contributing to lean mass variation remain largely unknown. We estimated the shared SNP …

Throughout life, bone is continuously remodelled to be able to fulfil its multiple functions. The
importance of strictly regulating the bone remodelling process, which is defined by the …

Osteoporosis is a common and debilitating bone disease that is characterised by low bone
mineral density, typically assessed using dual-energy X-ray absorptiometry. Quantitative …

The risk of fracture in individuals with Alzheimer's disease had not been fully quantified. A
systematic review and meta-analysis of cohort studies was performed to estimate the impact …

Osteoporosis is characterized by increased bone loss and deterioration of bone
microarchitecture, which will lead to reduced bone strength and increased risk of fragility …

Although many common variants have been identified for bone mineral density (BMD) and
osteoporosis fractures, all the identified risk variants could only explain a small portion of …