Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular …
O Friedrich, D Schneidereit, YA Nikolaev… - Progress in biophysics …, 2017 - Elsevier
Hollow organs (eg heart) experience pressure-induced mechanical wall stress sensed by
molecular mechano-biosensors, including mechanosensitive ion channels, to translate into …
molecular mechano-biosensors, including mechanosensitive ion channels, to translate into …
Long-term biased β-arrestin signaling improves cardiac structure and function in dilated cardiomyopathy
Background: Biased agonism of the angiotensin II receptor is known to promote cardiac
contractility. Our laboratory indicated that these effects may be attributable to changes at the …
contractility. Our laboratory indicated that these effects may be attributable to changes at the …
Monte Carlo simulations of diffusion weighted MRI in myocardium: validation and sensitivity analysis
A model of cardiac microstructure and diffusion MRI is presented, and compared with
experimental data from ex vivo rat hearts. The model includes a simplified representation of …
experimental data from ex vivo rat hearts. The model includes a simplified representation of …
Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells
SR Amith, KM Vincent, JM Wilkinson, LM Postovit… - Cellular signalling, 2017 - Elsevier
Mounting evidence supports a major role for the Na+/H+ exchanger NHE1 in cancer
progression and metastasis. NHE1 is hyperactive at the onset of oncogenic transformation …
progression and metastasis. NHE1 is hyperactive at the onset of oncogenic transformation …
Nitric oxide and CaMKII: Critical steps in the cardiac contractile response To IGF-1 and swim training
Cardiac adaptation to endurance training includes improved contractility by a non-yet
clarified mechanism. Since IGF-1 is the main mediator of the physiological response to …
clarified mechanism. Since IGF-1 is the main mediator of the physiological response to …
Moderate exercise training does not prevent the reduction in myocardial L‐type Ca2+ channels protein expression at obese rats
VL da Silva, AP Lima‐Leopoldo… - Physiological …, 2017 - Wiley Online Library
Authors have showed that obesity implicates cardiac dysfunction associated with myocardial
L‐type calcium channels (LTCCs) activity impairments, as well as moderate exercise …
L‐type calcium channels (LTCCs) activity impairments, as well as moderate exercise …
Protein mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells. A regulatory role of Hsp90 and AKT kinase
A Odunewu-Aderibigbe, L Fliegel - Cellular Signalling, 2017 - Elsevier
Na+/H+ exchanger isoform one (NHE1) is a pH regulatory protein that is present in renal
tissues and serves to remove protons from within cells and protect against intracellular …
tissues and serves to remove protons from within cells and protect against intracellular …