Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

TP53 missense mutations produce a mutant p53 protein that cannot activate the p53 tumor
suppressive transcriptional response, which is the primary selective pressure for TP53 …

The Hippo pathway is an oncosuppressor signalling cascade that plays a major role in the
control of cell growth, tissue homoeostasis and organ size. Dysregulation of the Hippo …

Abstract Wild-type p53 (wtp53) is described as a tumour suppressor gene; mutations in this
gene occur in many human cancers and promote oncogenic capacity. Here, we establish …

HDAC6-selective inhibitors represent promising new cancer therapeutic agents, but their
precise mechanisms of action are not well understood. In particular, p53's role in HDAC6 …

The TP 53 tumor suppressor is the most frequently mutated gene in human cancers. In
recent years, a blooming of research efforts based on both cell lines and mouse models …

Purpose: We previously demonstrated an association between decreased SMAD4
expression and cetuximab resistance in head and neck squamous cell carcinoma (HNSCC) …

Distant metastasis to specific target organs is responsible for over 90% of breast cancer-
related deaths, but the underlying molecular mechanism is unclear. Mounting evidence …

p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As
it has several and key functions exerted, p53 is known as “the guardian of the genome” and …

Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving
non-malignant cells unharmed. With the first US Food and Drug Administration-approved …